The match is scheduled for 7:00 p.m. in Guatemala and will mark the debut of the two teams in the tournament.
The American team, led by Mauricio Pochettino, will seek to start the competition with a positive result in front of its fans. Among its main figures are Christian Pulisic, Tyler Adams, Weston McKennie, Folarin Balogun and Tim Weah.
For its part, Paraguay returns to a World Cup after 16 years of absence. The team led by Gustavo Alfaro has players like Miguel Almirón, Antonio Sanabria, Andrés Cubas, Diego Gómez and Gustavo Gómez.
The possible absence of Julio Enciso due to injury represents one of the main doubts for Albirroja ahead of their debut. Group D also includes Australia and Türkiye.
The United States will try to start its twelfth participation in a World Cup with a positive result. The American team has won three games in its World Cup debut, tied three others and lost five.
Paraguay, for its part, has only achieved one victory in its debut in a World Cup, when it defeated Iraq in Mexico 1986. In its other debuts it recorded four draws and three losses.